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When THC reaches the brain, it attaches to cannabinoid receptors, an action which kicks off the high. Studies have shown that it has a direct affect on one’s episodic3 memory, and can create difficulty in thinking and problem solving, among other issues. A number of studies have made a direct link between marijuana use in high school and subsequently lower grades as well as higher drop-out rates compared to non-users.4
More relevant to our topic, research has shown that long-term use can create the same kinds of physiological changes in the brain as other drugs.5 These changes are significant in determining the addictive capacity of marijuana, but they are not alone in supporting the conclusion.
References
3. “Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users.” Psychopharmacology Laboratories, Clinical Health Psychology, University College London, Gower Street, London WC1 6BT, UK. v.curran@ucl.ac.uk
4. Lynskey M, Hall W. The effects of adolescent cannabis use on educational attainment: A review. Addiction 95(11):1621–1630, 2000.
Kandel DB, Davies M. High school students who use crack and other drugs. Arch Gen Psychiatry 53(1):71–80, 1996.
Rob M, Reynolds I, Finlayson PF. Adolescent marijuana use: Risk factors and implications. Aust NZ J Psychiatry 24(1):45–56, 1990.
Brook JS, Balka EB, Whiteman M. The risks for late adolescence of early adolescent marijuana use. Am J Public Health 89(10):1549–1554, 1999.
5. Rodriguez de Fonseca F, et al. Activation of cortocotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science 276(5321):2050–2054, 1997.
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